Abstract | PURPOSE/AIM: MATERIALS AND METHODS: A retrospective case-controlled study was performed in 22 patients with BRVO and macular edema, as well as 5 patients with non-ischemic ocular diseases as the control group. The severity of macular edema was examined by optical coherence tomography. Aqueous humor samples were obtained during intravitreous injection of anti- VEGF agents, triamcinolone acetonide, or combined vitrectomy and cataract surgery. sVEGFR-2 levels in aqueous humor were determined by enzyme-linked immunosorbent assay. RESULTS: The aqueous humor level of sVEGFR-2 (median: 124.5 ng/ml) was significantly elevated in BRVO patients compared with the control group (78.1 pg/ml) (p = 0.010). In addition, the sVEGFR-2 level was correlated with the severity of macular edema (p = 0.033). CONCLUSIONS: sVEGFR-2 may be involved in the pathogenesis of macular edema associated with BRVO. Measurement of aqueous humor sVEGFR-2 levels may be helpful for understanding the disease status in BRVO patients with macular edema.
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Authors | Hidetaka Noma, Tatsuya Mimura |
Journal | Current eye research
(Curr Eye Res)
Vol. 38
Issue 12
Pg. 1288-90
(Dec 2013)
ISSN: 1460-2202 [Electronic] England |
PMID | 23972086
(Publication Type: Journal Article)
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Chemical References |
- Vascular Endothelial Growth Factor Receptor-2
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Topics |
- Aged
- Aqueous Humor
(metabolism)
- Case-Control Studies
- Female
- Humans
- Macular Edema
(metabolism, pathology)
- Male
- Retinal Perforations
(metabolism, pathology)
- Retinal Vein Occlusion
(metabolism, pathology)
- Retrospective Studies
- Solubility
- Tomography, Optical Coherence
- Vascular Endothelial Growth Factor Receptor-2
(metabolism)
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