Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: a serological study.

Abstract

Serological surveillance conducted in areas of an outbreak of influenza A(H7N9) infection in China found no seropositivity for antibodies specific for avian-origin influenza A(H7N9) among 1129 individuals of the general population, whereas >6% of 396 poultry workers were positive (on the basis of a hemagglutination inhibition titer of ≥ 80) for this subtype, confirming that infected poultry is the principal source of human infections and that subclinical infections are possible. Fourteen days after symptom onset, elevated levels of antibodies to A(H7N9) were found in 65.8% of patients (25/38) who survived but in only 28.6% of those (2/7) who died, suggesting that the presence of antibodies may improve clinical outcome in infected patients.

• Authors: Shigui Yang, Yu Chen, Dawei Cui, Hangping Yao, Jianzhou Lou, Zhaoxia Huo, Guoliang Xie, Fei Yu, Shufa Zheng, Yida Yang, Yixin Zhu, Xiaoqing Lu, Xiaoli Liu, Siu-Ying Lau, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Kwok-Yung Yuen, Honglin Chen, Lanjuan Li
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 209 Issue 2 Pg. 265-9 (Jan 15 2014) ISSN: 1537-6613 [Electronic] United States
• PMID: 23935201 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antibodies, Viral (blood)
• Child
• Child, Preschool
• China (epidemiology)
• Female
• Hemagglutination Inhibition Tests
• Humans
• Infant
• Influenza A Virus, H7N9 Subtype (isolation & purification)
• Influenza, Human (epidemiology, immunology, virology)
• Male
• Middle Aged
• Occupational Exposure
• Seroepidemiologic Studies
• Survival Analysis
• Young Adult