Anorgasmia during pregabalin add-on therapy for partial seizures.

Abstract

Anorgasmia is the inability to reach orgasm during sexual intercourse, and, although it is believed that around 90% of anorgasmia problems are related to psychological issues, the use of serotoninergic drugs, including antidepressants and atypical antipsychotics, is a common cause of situational anorgasmia. Pregabalin is a new antiepileptic drug, structurally related to gabapentin, and commonly used as adjunctive therapy for partial epilepsy and treatment of neuropathic pain in adults. Herein, we describe three men with epilepsy, who experienced severe anorgasmia after pregabalin add-on treatment.

• Authors: Rocco Salvatore Calabrò, Rosaria De Luca, Patrizia Pollicino, Placido Bramanti
• Journal: Epileptic disorders : international epilepsy journal with videotape (Epileptic Disord) Vol. 15 Issue 3 Pg. 358-61 (Sep 2013) ISSN: 1294-9361 [Print] France
• PMID: 23906723 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Pregabalin
• gamma-Aminobutyric Acid

Topics

• Adult
• Anticonvulsants (adverse effects, therapeutic use)
• Drug Therapy, Combination
• Electroencephalography
• Epilepsies, Partial (complications, drug therapy)
• Humans
• Magnetic Resonance Imaging
• Male
• Orgasm (drug effects)
• Pregabalin
• Sexual Dysfunctions, Psychological (chemically induced, complications)
• Young Adult
• gamma-Aminobutyric Acid (adverse effects, analogs & derivatives, therapeutic use)