Role of insulin resistance and adipocytokines on serum alanine aminotransferase in obese patients with type 2 diabetes mellitus.

Abstract

BACKGROUND AND OBJECTIVE:

The aim of our study was to study the association of insulin resistance expressed by HOMA and adipokines in obese type 2 diabetic patients with or without hyper-transaminasemia.

SUBJECTS AND METHODS:

A population of 72 obese patients with type 2 diabetes mellitus was analyzed. HOMA-IR was calculated as indicator of insulin-resistance. Adipocytokines blood levels were measured.

RESULTS:

Patients were classified as group I (n=37) when serum ALT activity was normal or group II (NAFLD patients: n=35) when serum ALT activity was greater than the median value of the group (≥ 28 UI/L). In NAFLD group, BMI, weight, fat mass, waist to hip ratio, waist circumference, triglycerides, HOMA and insulin levels were higher than control group. In the logistic regression analysis with a dependent variable (ALT) and the statistical univariant variables as independent variables, the HOMA-IR remained in the model, with an Odd's ratio of 1.21 (CI:95%: 1.11-1.35) to have a high ALT level with each 1 unit of HOMA-IR adjusted by age, sex, weight, and dietary intake.

CONCLUSIONS:

Some metabolic parameters are associated with elevated ALT in female obese patients. However, adjusted by other variables, only insulin resistance remained associated.

• Authors: D A de Luis, R Aller, O Izaola, M Gonzalez Sagrado, R Conde, B de la Fuente
• Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) Vol. 17 Issue 15 Pg. 2059-64 ( 2013) ISSN: 2284-0729 [Electronic] Italy
• PMID: 23884827 (Publication Type: Journal Article)

Chemical References

• Adipokines
• Blood Glucose
• Triglycerides
• Cholesterol
• Alanine Transaminase

Topics

• Adipokines (blood)
• Adult
• Aged
• Alanine Transaminase (blood)
• Blood Glucose (analysis)
• Body Fat Distribution
• Body Mass Index
• Body Size
• Cholesterol (blood)
• Diabetes Mellitus, Type 2 (blood, epidemiology)
• Female
• Humans
• Insulin Resistance
• Male
• Middle Aged
• Non-alcoholic Fatty Liver Disease (blood, epidemiology)
• Obesity (blood, epidemiology)
• Odds Ratio
• Spain (epidemiology)
• Triglycerides (blood)