Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: Patients with the C/C genotype of SNP 83 exhibited significantly more cognitive dysfunction at 1 day (29.7%) than the C/T (15.8%, P = .008) and T/T (12.7%, P = .01) genotypes. In a multivariate logistic regression model, C/T and T/T genotypes were both associated with significantly decreased odds of cognitive dysfunction compared with the C/C genotype (odds ratio, 0.45 [0.24-0.83], P = .01 and odds ratio, 0.33 [0.12-0.77], P = .02). There were no significant associations at 1 month. CONCLUSION: The C/C genotype of SNP 83 is significantly associated with the highest incidence of cognitive dysfunction 1 day following CEA in comparison with the C/T and T/T genotypes. This PDE4D genotype may lead to accelerated cyclic AMP degradation and subsequently elevated inflammation 1 day after CEA. These observations, in conjunction with previous studies, suggest that elevated inflammatory states may be partially responsible for the development of cognitive dysfunction after CEA, but more investigation is required.
|
Authors | Eric J Heyer, Joanna L Mergeche, Justin T Ward, Hani R Malone, Christopher Kellner, Samuel S Bruce, E Sander Connolly |
Journal | Neurosurgery
(Neurosurgery)
Vol. 73
Issue 5
Pg. 791-6; discussion 796
(11 2013)
ISSN: 1524-4040 [Electronic] United States |
PMID | 23863764
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Cyclic Nucleotide Phosphodiesterases, Type 4
|
Topics |
- Aged
- Aged, 80 and over
- Carotid Stenosis
(genetics, surgery)
- Cognition Disorders
(etiology, genetics)
- Cohort Studies
- Cyclic Nucleotide Phosphodiesterases, Type 4
(genetics)
- Endarterectomy, Carotid
- Female
- Genotype
- Humans
- Male
- Neuropsychological Tests
- Polymorphism, Single Nucleotide
(genetics)
- Postoperative Complications
(genetics)
- Regression Analysis
- Statistics, Nonparametric
|