[Protein kinases role in adaptive phenomenon of heart ischemic postconditioning development].

Abstract

Authors submitted an analysis of papers given up an involvement of protein kinases in heart ischemic postconditioning. This analysis of literature source allowed to authors affirms that signaling system of postconditioning can involve kinases: PKC, PI3K, Akt, MEKl/2, ERK1/2, MTOR, p70s6K, GSK3b, PKG and also eNOS, NO, GC, motoKATP channel, ROS, MPT pore. At the same time it is unclear a real contributions of kinases mTOR, p70s6, AMPK and GSK3b in the mechanism of infarct limiting impact of postconditioning. It is required a further study of the chain of signaling events following JAK2 and p38 kinase activation. The knowledge of Ras and Raf-1 role in postconditioning has hypothetical character. The tyrosine kinase significance in postcondi-tioning is unclear, particular Src kinase, which plays an important role in the regulation of cardiac tolerance to an impact of ischemia and reperfusion.

• Authors: L N Maslov, A G Mrochek, I A Shchepetkin, J P Headrick, L Hanus, E I Barzakh, A Iu Lishmanov, A S Gorbunov, S Iu Tsybul'nikov, A N Baĭkov
• Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (Ross Fiziol Zh Im I M Sechenova) Vol. 99 Issue 4 Pg. 433-52 (Apr 2013) ISSN: 0869-8139 [Print] Russia (Federation)
• PMID: 23862384 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Protein Kinases

Topics

• Adaptation, Physiological (genetics)
• Animals
• Humans
• Ischemic Postconditioning
• Myocardial Infarction (metabolism, physiopathology)
• Protein Kinases (chemistry, classification, metabolism, physiology)
• Reperfusion
• Signal Transduction (genetics)