[The use of T-activin for the prevention of congenital influenzal infection in mice and the correction of the immune deficiency].

Abstract

Viremia accompanying influenza infection and the possibility of transplacental passage of the virus into the fetus make it expedient to develop measures for the prophylaxis of intrauterine infection of the fetus in case of influenza during pregnancy. The work presents the optimum scheme of administration of T-activin for prophylactic purposes to pregnant mice with acute influenza infection. Besides, the use of T-activin for immunocorrection in case of established congenital influenza infection in mice is proposed.

• Authors: E P Mirchink, A V Pronin, V Ia Arion, A V Deeva, I V Zimina, V A Zuev
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 4 Pg. 60-4 (Apr 1990) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Ispol'zovanie T-aktivina dlia profilaktiki vrozhdennoĭ grippoznoĭ infektsii u mysheĭ i korrektsii immunodefitsita.
• PMID: 2385991 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Peptides
• Thymus Extracts
• T-activin

Topics

• Adjuvants, Immunologic (therapeutic use)
• Animals
• Antibody-Producing Cells (drug effects, immunology)
• Drug Evaluation, Preclinical
• Female
• Fetal Diseases (immunology, prevention & control)
• Immunologic Deficiency Syndromes (congenital, drug therapy, immunology)
• Influenza A virus
• Mice
• Mice, Inbred C57BL
• Orthomyxoviridae Infections (congenital, immunology, prevention & control)
• Peptides (therapeutic use)
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy, immunology)
• Rosette Formation
• Spleen (drug effects, immunology)
• Thymus Extracts (therapeutic use)
• Time Factors