Susceptibility loci associations with prostate cancer risk in northern Chinese men.

Abstract

BACKGROUND:

KLK3 gene products, like human prostate-specific antigen (PSA), are important biomarkers in the clinical diagnosis of prostate cancer (PCa). G protein-coupled receptor RFX6, C2orf43 and FOXP4 signaling plays important roles in the development of PCa. However, associations of these genes with PCa in northern Chinese men remain to be detailed. This study aimed to investigate their impact on occurrence and level of malignancy.

METHODS:

All subjects were from Beijing and Tianjin, including 266 cases with prostate cancer and 288 normal individuals as controls. We evaluated associations between clinical covariates (age at diagnosis, prostate specific antigen, Gleason score, tumor stage and aggressive) and 6 candidate PCa risk loci, genotyped by PCR- high resolution melting curve and sequencing methods.

RESULTS:

Case-control analysis of allelic frequency of PCa associated with PCa showed that one of the 6 candidate risk loci, rs339331 in the RFX6 gene, was associated with reduced risk of prostate cancer (odds ratio (OR) = 0.73, 95% confidence interval (CI) =0.57-0.94, P = 0.013) in northern Chinese men. In addition, subjects with CX (CC+TC) genotypes had a decreased risk for prostrate cancer compared to those carrying the TT homozygote (OR =0.64, 95% CI = 0.45- 0.90, P = 0.008). The TT genotype of 13q22 (rs9600079, T) was associated with tumor stage (P=0.044, OR=2.34, 95% CI=0.94-5.87). Other SNPs were not significantly associated with clinical covariates in prostate cancer (P > 0.05). CONCLUSIONS. rs339331 in the RFX6 gene may be associated with prostate cancer as a susceptibility locus in northern Chinese men.

• Authors: Na-Na Wang, Yong Xu, Kuo Yang, Dong Wei, Yao-Guang Zhang, Ming Liu, Xiao-Hong Shi, Si-Ying Liang, Liang Sun, Xiao-Quan Zhu, Yi-Ge Yang, Lei Tang, Cheng-Xiao Zhao, Xin Wang, Xin Chen, Juan Hui, Yu-Hong Zhang, Ling Zhu, Fan Yang, Yu-Rong Zhang, Ze Yang, Jian-Ye Wang
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 14 Issue 5 Pg. 3075-8 ( 2013) ISSN: 2476-762X [Electronic] Thailand
• PMID: 23803082 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• DNA-Binding Proteins
• Regulatory Factor X Transcription Factors
• Rfx6 protein, human
• Transcription Factors

Topics

• Aged
• Asian People (genetics)
• Biomarkers, Tumor (genetics)
• Case-Control Studies
• DNA-Binding Proteins (genetics)
• Follow-Up Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Middle Aged
• Neoplasm Grading
• Neoplasm Staging
• Polymorphism, Single Nucleotide (genetics)
• Prognosis
• Prostate (metabolism)
• Prostatic Neoplasms (genetics, pathology)
• Regulatory Factor X Transcription Factors
• Risk Factors
• Transcription Factors (genetics)