Abstract | BACKGROUND: METHODS: Sixty-two patients were randomly assigned to receive a 2 % diltiazem gel (n = 32) or a placebo gel ( n = 30) after hemorrhoidectomy. Patients applied the gel to the anal region three times per day for 14 days. Pain both in the resting state and on defecation ranged from 0 to 10 on a numerical rating scale, and the number of prescribed loxoprofen tablets (Loxonin) were recorded and confirmed daily by telephone. Any morbidity during the follow-up period was recorded. RESULTS: Both pain scores during defecation and the number of analgesic tablets consumed tended to be lower in the diltiazem group, although they did not reach statistical significance (P = 0.09, P = 0.12, respectively). Total number of complications was significantly higher in the diltiazem group, but each incidence of complications, including itching sensation, headache, and dizziness was not statistically different. CONCLUSIONS:
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Authors | Takuya Sugimoto, Akira Tsunoda, Nobuyasu Kano, Yasuharu Kashiwagura, Ken-Ichi Hirose, Tadanori Sasaki |
Journal | World journal of surgery
(World J Surg)
Vol. 37
Issue 10
Pg. 2454-7
(Oct 2013)
ISSN: 1432-2323 [Electronic] United States |
PMID | 23775515
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Calcium Channel Blockers
- Gels
- Diltiazem
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Topics |
- Administration, Topical
- Aged
- Calcium Channel Blockers
(therapeutic use)
- Diltiazem
(therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Female
- Follow-Up Studies
- Gels
- Hemorrhoidectomy
- Hemorrhoids
(surgery)
- Humans
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Prospective Studies
- Treatment Outcome
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