Abstract |
The neuromuscular blocking properties of AH 8165 D (1,1'azobis-(3-methyl-2-phenyl-1H-imidazo-1,2a-pyridinium)dibromide) were quantitatively studied in 50 patients, undergoing extra-abdominal surgery and anaesthetized with barbiturates, nitrous oxide, fentanyl and droperidol, by means of mechanograms of the hand muscles obtained by ulnar nerve stimulation. AH 8165 D is a rapid-acting nondepolarizing agent (full effect within 1--2 min) providing good intubation conditions similar to those obtained with suxamethonium. AH 8165 D may be considered to be indicated for emergency intubation in patients with full stomach when the risk of regurgitation is high. The duration of action of clinically useful doses (0.4-0.8 mg/kg body weight) is shorter than that of equi-effective doses of other nondepolarizing muscle relaxants. Repeated doses show a cumulative effect. The neuromuscular blockade can easily be reversed by an anticholinesterase drug. AH 8165 D-induced muscle relaxation is always accompanied by a dose-dependent tachycardia limiting the clinical usefulness of this new drug.
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Authors | F T Schuh |
Journal | Der Anaesthesist
(Anaesthesist)
Vol. 24
Issue 4
Pg. 151-6
(Apr 1975)
ISSN: 0003-2417 [Print] Germany |
PMID | 237423
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Neuromuscular Nondepolarizing Agents
- Pyridinium Compounds
- Neostigmine
|
Topics |
- Adult
- Cardiac Output
(drug effects)
- Dose-Response Relationship, Drug
- Drug Evaluation
- Female
- Heart Rate
(drug effects)
- Humans
- Male
- Middle Aged
- Muscle Contraction
(drug effects)
- Neostigmine
(pharmacology)
- Neuromuscular Junction
(drug effects)
- Neuromuscular Nondepolarizing Agents
(administration & dosage, pharmacology)
- Pulse
(drug effects)
- Pyridinium Compounds
(administration & dosage, pharmacology)
- Time Factors
- Ulnar Nerve
(drug effects)
- Vascular Resistance
(drug effects)
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