Eradication of breast cancer with bone metastasis by autologous formalin-fixed tumor vaccine (AFTV) combined with palliative radiation therapy and adjuvant chemotherapy: a case report.

Abstract	Skeletal metastasis of breast carcinoma is refractory to intensive chemo-radiation therapy and therefore is assumed impossible to cure. Here, we report an advanced case of breast cancer with vertebra-Th7 metastasis that showed complete response to combined treatments with formalin-fixed autologous tumor vaccine (AFTV), palliative radiation therapy with 36 Gy, and adjuvant chemotherapy with standardized CEF (cyclophosphamide, epirubicin, and 5FU), zoledronic acid, and aromatase inhibitors following mastectomy for the breast tumor. The patient has been disease-free for more than 4 years after the mammary surgery and remains well with no evidence of metastasis or local recurrence. Thus, a combination of AFTV, palliative radiation therapy, and adjuvant chemotherapy may be an effective treatment for this devastating disease.
Authors	Fumito Kuranishi, Tadao Ohno
Journal	World journal of surgical oncology (World J Surg Oncol) Vol. 11 Pg. 127 (Jun 04 2013) ISSN: 1477-7819 [Electronic] England
PMID	23734861 (Publication Type: Case Reports, Journal Article)
Chemical References	Androstadienes Autoantigens Cancer Vaccines Diphosphonates Fixatives Imidazoles Nitriles Triazoles Formaldehyde Anastrozole Epirubicin Zoledronic Acid Cyclophosphamide exemestane Fluorouracil
Topics	Anastrozole Androstadienes (administration & dosage) Antineoplastic Combined Chemotherapy Protocols (therapeutic use) Autoantigens (administration & dosage) Bone Neoplasms (secondary, therapy) Breast Neoplasms (pathology, therapy) Cancer Vaccines (administration & dosage) Chemotherapy, Adjuvant Combined Modality Therapy Cyclophosphamide (administration & dosage) Diphosphonates (administration & dosage) Epirubicin (administration & dosage) Female Fixatives Fluorouracil (administration & dosage) Formaldehyde (administration & dosage) Humans Imidazoles (administration & dosage) Magnetic Resonance Imaging Mastectomy Middle Aged Neoplasm Recurrence, Local (pathology, therapy) Nitriles (administration & dosage) Prognosis Radiotherapy Dosage Tomography, Emission-Computed, Single-Photon Triazoles (administration & dosage) Zoledronic Acid

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