Abstract | BACKGROUND: METHODS: We compared regional grey matter volumes of 10 non-medicated male ADHD patients with comorbid cocaine dependence, 14 non-medicated male ADHD patients without cocaine dependence and 15 healthy control participants matched for age and premorbid intellectual functioning, using voxel-based morphometry (VBM) using both a whole-brain analysis and a priori ROI analysis based on the existing ADHD VBM literature. RESULTS: In a whole brain analysis, ADHD patients with and without cocaine dependence showed smaller volumes in the right putamen and cerebellum compared to healthy controls. In addition, ADHD patients without cocaine dependence showed larger volumes in the midbrain and in the precentral gyrus compared to healthy control participants and larger volumes in the occipital cortex compared to ADHD patients with comorbid cocaine dependence. A direct comparison using the a priori defined ROI approach showed that ADHD patients with cocaine dependence had smaller putamen volumes than ADHD patients without cocaine dependence. CONCLUSIONS:
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Authors | Guido A van Wingen, Wim van den Brink, Dick J Veltman, Lianne Schmaal, Geert Dom, Jan Booij, Cleo L Crunelle |
Journal | Drug and alcohol dependence
(Drug Alcohol Depend)
Vol. 131
Issue 3
Pg. 198-203
(Aug 01 2013)
ISSN: 1879-0046 [Electronic] Ireland |
PMID | 23726981
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
Topics |
- Adult
- Attention Deficit Disorder with Hyperactivity
(epidemiology, pathology)
- Cocaine-Related Disorders
(epidemiology, pathology)
- Comorbidity
- Corpus Striatum
(pathology)
- Cross-Sectional Studies
- Humans
- Male
- Middle Aged
- Organ Size
- Young Adult
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