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Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors.

Abstract
Thiol-ene click chemistry has been applied for obtaining sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors incorporating sugar moieties. Most of these new compounds were moderate CA I inhibitors, effective CA II inhibitors, and low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms CA IX and XII.
AuthorsMohamed-Chiheb Saada, Joanna Ombouma, Jean-Louis Montero, Claudiu T Supuran, Jean-Yves Winum
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 49 Issue 50 Pg. 5699-701 (Jun 25 2013) ISSN: 1364-548X [Electronic] England
PMID23689938 (Publication Type: Journal Article)
Chemical References
  • Carbohydrates
  • Carbonic Anhydrase Inhibitors
  • Sulfhydryl Compounds
  • Sulfonamides
Topics
  • Carbohydrates (chemistry)
  • Carbonic Anhydrase Inhibitors (chemistry)
  • Click Chemistry
  • Sulfhydryl Compounds (chemistry)
  • Sulfonamides (chemistry)

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