Abstract |
Thiol-ene click chemistry has been applied for obtaining sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors incorporating sugar moieties. Most of these new compounds were moderate CA I inhibitors, effective CA II inhibitors, and low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms CA IX and XII.
|
Authors | Mohamed-Chiheb Saada, Joanna Ombouma, Jean-Louis Montero, Claudiu T Supuran, Jean-Yves Winum |
Journal | Chemical communications (Cambridge, England)
(Chem Commun (Camb))
Vol. 49
Issue 50
Pg. 5699-701
(Jun 25 2013)
ISSN: 1364-548X [Electronic] England |
PMID | 23689938
(Publication Type: Journal Article)
|
Chemical References |
- Carbohydrates
- Carbonic Anhydrase Inhibitors
- Sulfhydryl Compounds
- Sulfonamides
|
Topics |
- Carbohydrates
(chemistry)
- Carbonic Anhydrase Inhibitors
(chemistry)
- Click Chemistry
- Sulfhydryl Compounds
(chemistry)
- Sulfonamides
(chemistry)
|