Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: KEY RESULTS:
Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARα and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor α, as well as elevation of ROS and IL-1β in diabetic rat liver. These effects were confirmed in hepatocytes in vitro and it was further shown that TXNIP down-regulation contributed to the suppression of NLRP3 inflammasome activation, inflammation and changes in PPARα and SREBPs. CONCLUSIONS AND IMPLICATIONS:
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Authors | Wei Wang, Chuang Wang, Xiao-Qin Ding, Ying Pan, Ting-Ting Gu, Ming-Xing Wang, Yang-Liu Liu, Fu-Meng Wang, Shui-Juan Wang, Ling-Dong Kong |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 169
Issue 6
Pg. 1352-71
(Jul 2013)
ISSN: 1476-5381 [Electronic] England |
PMID | 23647015
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 The British Pharmacological Society. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Antioxidants
- Carrier Proteins
- Cell Cycle Proteins
- Inflammasomes
- Reactive Oxygen Species
- TXNIP protein, rat
- Allopurinol
- Quercetin
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Topics |
- Allopurinol
(pharmacology, therapeutic use)
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, metabolism, pharmacology, therapeutic use)
- Antioxidants
(administration & dosage, metabolism, pharmacology, therapeutic use)
- Carrier Proteins
(antagonists & inhibitors, genetics, metabolism)
- Cell Cycle Proteins
- Cell Line
- Diabetes Mellitus, Type 1
(complications)
- Dietary Supplements
- Fatty Liver
(complications, metabolism, pathology, prevention & control)
- Gene Silencing
- Humans
- Inflammasomes
(drug effects, metabolism)
- Lipid Metabolism
(drug effects)
- Liver
(drug effects, immunology, metabolism, pathology)
- Male
- Molecular Targeted Therapy
- Non-alcoholic Fatty Liver Disease
- Oxidative Stress
(drug effects)
- Quercetin
(administration & dosage, metabolism, therapeutic use)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species
(antagonists & inhibitors, metabolism)
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