Abstract | BACKGROUND: OBJECTIVE: The purpose of this study is to determine mechanisms by which PCB 153 worsens diet-induced obesity and NAFLD in male mice fed a high-fat diet (HFD). METHODS: Male C57BL6/J mice were fed either control or 42% milk fat diet for 12 weeks with or without PCB 153 coexposure (50 mg/kg ip ×4). Glucose tolerance test was performed, and plasma and tissues were obtained at necropsy for measurements of adipocytokine levels, histology and gene expression. RESULTS: CONCLUSION:
PCB 153 is an obesogen that exacerbates hepatic steatosis, alters adipocytokines and disrupts normal hepatic lipid metabolism when administered with HFD but not control diet. Because all US adults have been exposed to PCB 153, this particular nutrient-toxicant interaction potentially impacts human obesity/ NAFLD.
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Authors | Banrida Wahlang, K Cameron Falkner, Bonnie Gregory, Douglas Ansert, David Young, Daniel J Conklin, Aruni Bhatnagar, Craig J McClain, Matt Cave |
Journal | The Journal of nutritional biochemistry
(J Nutr Biochem)
Vol. 24
Issue 9
Pg. 1587-95
(Sep 2013)
ISSN: 1873-4847 [Electronic] United States |
PMID | 23618531
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Adiponectin
- Environmental Pollutants
- Leptin
- Plasminogen Activator Inhibitor 1
- Resistin
- Polychlorinated Biphenyls
- 2,4,5,2',4',5'-hexachlorobiphenyl
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Topics |
- Adiponectin
(blood)
- Animals
- Diet, High-Fat
- Disease Models, Animal
- Environmental Pollutants
(administration & dosage, blood, toxicity)
- Fatty Liver
(blood, chemically induced)
- Glucose Tolerance Test
- Insulin Resistance
- Leptin
(blood)
- Lipogenesis
- Liver
(drug effects, pathology)
- Male
- Mice
- Mice, Inbred C57BL
- Non-alcoholic Fatty Liver Disease
- Obesity
(blood, chemically induced)
- Plasminogen Activator Inhibitor 1
(blood)
- Polychlorinated Biphenyls
(administration & dosage, blood, toxicity)
- Resistin
(blood)
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