Interaction between endogenous bacterial flora and latent HIV infection.

Abstract

Human commensal bacteria do not normally cause any diseases. However, in certain pathological conditions, they exhibit a number of curious behaviors. In HIV infection, these bacteria exhibit bidirectional relationships: whereas they cause opportunistic infections based on immunological deterioration, they also augment HIV replication, in particular, viral replication from latently infected cells, which is attributable to the effect of butyric acid produced by certain anaerobic bacteria by modifying the state of chromatin. Here, we review recent evidence supporting the contributory role of such endogenous microbes in disrupting HIV latency and its potential link to the clinical progression of AIDS.

• Authors: Ann Florence B Victoriano, Kenichi Imai, Takashi Okamoto
• Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 20 Issue 6 Pg. 773-9 (Jun 2013) ISSN: 1556-679X [Electronic] United States
• PMID: 23616411 (Publication Type: Journal Article, Review)

Topics

• AIDS-Related Opportunistic Infections (epidemiology)
• Bacteria (growth & development, immunology, pathogenicity)
• Bacterial Infections (epidemiology)
• HIV (growth & development)
• HIV Infections (immunology, virology)
• Humans
• Microbial Interactions
• Microbiota