High-sensitive cardiac troponin T.

Abstract

Cardiac troponin is the preferred biomarker for the diagnosis of acute myocardial infarction (AMI). The recent development of a high-sensitive cardiac troponin T (hs-cTnT) assay permits detection of very low levels of cTnT. Using the hs-cTnT assay improves the overall diagnostic accuracy in patients with suspected AMI, while a negative result also has a high negative predictive value. The gain in sensitivity may be particularly important in patients with a short duration from symptom onset to admission. Measurement of cardiac troponin T with the hs-cTnT assay may provide strong prognostic information in patients with acute coronary syndromes, stable coronary artery disease, heart failure and even in the general population; however, increased sensitivity comes at a cost of decreased specificity. Serial testing, as well as clinical context and co-existing diseases, are likely to become increasingly important for the interpretation of hs-cTnT assay results.

• Authors: Ru-Yi Xu, Xiao-Fa Zhu, Ye Yang, Ping Ye
• Journal: Journal of geriatric cardiology : JGC (J Geriatr Cardiol) Vol. 10 Issue 1 Pg. 102-9 (Mar 2013) ISSN: 1671-5411 [Print] China
• PMID: 23610580 (Publication Type: Journal Article)