IL-36 receptor antagonist with special emphasis on IL-38.

Abstract

IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFkB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

• Authors: Y Shaik, G Sabatino, G Maccauro, G Varvara, G Murmura, A Saggini, M Rosati, F Conti, E Cianchetti, A Caraffa, P Antinolfi, F Pandolfi, G Potalivo, R Galzio, P Conti, T C Theoharides
• Journal: International journal of immunopathology and pharmacology (Int J Immunopathol Pharmacol) 2013 Jan-Mar Vol. 26 Issue 1 Pg. 27-36 ISSN: 0394-6320 [Print] England
• PMID: 23527706 (Publication Type: Editorial, Review)

Chemical References

• Anti-Inflammatory Agents
• IL-38 protein, human
• Interleukins
• Receptors, Interleukin
• interleukin-36 receptor, human

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Humans
• Interleukins (immunology)
• Receptors, Interleukin (antagonists & inhibitors, immunology)