Abstract | PURPOSE: The objective of this study was to investigate the association of endothelial-related markers with organ dysfunction and in-hospital mortality to validate our earlier findings in a multicenter study. We hypothesize that (i) endothelial biomarkers will be associated with organ dysfunction and mortality in sepsis and that (ii) soluble fms-like tyrosine kinase 1 (sFlt-1) holds promise as a novel prognostic marker in sepsis. METHODS: RESULTS: CONCLUSIONS: This multicenter validation study confirms that markers of endothelial activation are associated with sepsis severity, organ dysfunction, and mortality in sepsis. This supports the hypothesis that the endothelium plays a central role in the pathophysiology of sepsis and may serve as a more accurate prediction tool and a target for therapies aimed at ameliorating endothelial cell dysfunction. In addition, sFLT-1 holds promise as a novel sepsis severity biomarker.
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Authors | Simon Skibsted, Alan E Jones, Michael A Puskarich, Ryan Arnold, Robert Sherwin, Stephen Trzeciak, Philipp Schuetz, William C Aird, Nathan I Shapiro |
Journal | Shock (Augusta, Ga.)
(Shock)
Vol. 39
Issue 5
Pg. 427-32
(May 2013)
ISSN: 1540-0514 [Electronic] United States |
PMID | 23524845
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- E-Selectin
- Plasminogen Activator Inhibitor 1
- Intercellular Adhesion Molecule-1
- Vascular Endothelial Growth Factor Receptor-1
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Topics |
- Adult
- Aged
- Biomarkers
(blood)
- E-Selectin
(blood)
- Endothelial Cells
(metabolism)
- Female
- Hospital Mortality
- Humans
- Intercellular Adhesion Molecule-1
(blood)
- Male
- Middle Aged
- Plasminogen Activator Inhibitor 1
(blood)
- Prospective Studies
- Sepsis
(blood, metabolism)
- Vascular Endothelial Growth Factor Receptor-1
(blood)
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