[A case of adenocarcinoma of small intestine surviving for many years].

Abstract

In adenocarcinoma of the small intestine, delays in diagnosis are frequent. The majority of patients present with advancedstage disease, and have either lymph node involvement or distant metastatic disease. Surgical resection is a mainstay in treatment of this disease, and the effectiveness of chemotherapy for advanced-stage or metastatic disease has been reported. We report a case of adenocarcinoma of the small intestine surviving for many years after surgical resection and chemotherapy. A 47-year-old woman underwent a small intestine resection, because she had a small intestinal tumor with obstruction. Histopathological examination revealed moderately-differentiated adenocarcinoma with lymph node metastasis. Adjuvant chemotherapy with S-1 was administered for a year, but in March 2006, a recurrent lesion at the right ovary was detected, and she underwent right adnexectomy. Because the ascites cytology revealed class V, chemotherapy was administered. In December 2008, CA19-9 elevated and magnetic resonance imaging showed a tumor behind the uterus, which was diagnosed as a recurrent disease. Because the tumor invaded the rectum, she received a low anterior resection, hysterectomy, and left adnexectomy. After surgical resection, UFT/UZEL was administered for half a year. In July 2010, computed tomography showed multiple lung metastases, and chemotherapy was performed again. However, the regimen was changed because her tumor marker elevated. She is being treated using a combination of cisplatin and irinotecan.

• Authors: Sho Sawazaki, Hiroyuki Saeki, Norihisa Tominaga, Yuko Shimada, Shigeya Hayashi, Ken Takata, Naoto Kato, Hiroyuki Osawa, Jun Fujisawa, Hiroshi Matsukawa, Naomi Kawano, Yasushi Rino, Munetaka Masuda
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 3 Pg. 393-5 (Mar 2013) ISSN: 0385-0684 [Print] Japan
• PMID: 23507606 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adenocarcinoma (drug therapy, secondary, surgery)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Female
• Humans
• Intestinal Neoplasms (drug therapy, pathology, surgery)
• Lymphatic Metastasis
• Middle Aged
• Retroperitoneal Neoplasms (drug therapy, secondary)
• Time Factors