Abstract | OBJECTIVES: METHODS: Groups of 8-10 female adult Wistar rats (200-250 g) housed individually were used. Gut paracellular permeability was evaluated after 2 h of partial restraint stress using oral gavage with ⁵¹Cr- EDTA and 24 h of urine collection. The number of abdominal cramps during colonic distension was evaluated in animals equipped with electrodes on their abdominal striated muscles. KEY FINDINGS: CONCLUSIONS: We conclude that both simethicone and alverine have visceral antinociceptive effects by two different mechanisms and that simethicone exerts a potentiating effect on the antinociceptive action of alverine.
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Authors | Lionel Bueno, Catherine Beaufrand, Vassilia Theodorou, Marie-Christine Andro-Delestrain |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 65
Issue 4
Pg. 567-73
(Apr 2013)
ISSN: 2042-7158 [Electronic] England |
PMID | 23488786
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 The Authors. JPP © 2013. Royal Pharmaceutical Society. |
Chemical References |
- Antifoaming Agents
- Gastrointestinal Agents
- Parasympatholytics
- Propylamines
- Protective Agents
- alverine
- Simethicone
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Topics |
- Animals
- Antifoaming Agents
(therapeutic use)
- Colic
(etiology, prevention & control)
- Colon
(drug effects, metabolism)
- Dilatation, Pathologic
(physiopathology)
- Disease Models, Animal
- Disease Resistance
(drug effects)
- Drug Synergism
- Female
- Gastrointestinal Agents
(agonists, therapeutic use)
- Intestinal Mucosa
(drug effects, metabolism)
- Irritable Bowel Syndrome
(drug therapy, physiopathology, psychology)
- Parasympatholytics
(therapeutic use)
- Permeability
(drug effects)
- Propylamines
(agonists, therapeutic use)
- Protective Agents
(therapeutic use)
- Rats
- Rats, Wistar
- Simethicone
(therapeutic use)
- Stress, Psychological
(physiopathology)
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