Abstract | BACKGROUND: METHODS: Enterally fed patients (n = 40; aged 60-80 years) were recruited in the first 48 hours of intensive care unit (ICU) admission. Fifteen patients received IV FLE (0.2 g/kg body weight) over 6 hours for 3 consecutive days, and 25 patients did not receive IV lipid (control). Samples were collected before and 24 hours and 72 hours after the third FLE infusion. Nutrient intakes, clinical parameters, and serum cytokine concentrations were measured. RESULTS: Compared with the control, FLE resulted in higher energy intake, lower serum tumor necrosis factor-α and interleukin (IL)-8 concentrations, and higher serum IL-10. These differences occurred around 7-9 days of ICU stay at the time of the patient's extubation. ICU stay, mortality, and markers of coagulation and liver function did not differ between groups. CONCLUSIONS: Short-term IV FLE modulates some inflammatory markers in critically ill elderly patients receiving enteral nutrition (EN), suggesting an anti-inflammatory effect. This may be a benefit and suggests a role for FLE administration as a supplement in elderly ICU patients receiving standard EN.
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Authors | Karina V Barros, Ana Paula Cassulino, Lívia Schalch, Eduardo Della Valle Munhoz, José Antônio Manetta, Philip C Calder, Vera L Flor Silveira |
Journal | JPEN. Journal of parenteral and enteral nutrition
(JPEN J Parenter Enteral Nutr)
Vol. 38
Issue 4
Pg. 467-74
(May 2014)
ISSN: 1941-2444 [Electronic] United States |
PMID | 23471207
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Emulsions
- Fatty Acids, Omega-3
- Fish Oils
- Inflammation Mediators
- Interleukin-8
- Tumor Necrosis Factor-alpha
- Interleukin-10
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Topics |
- Aged
- Critical Illness
(therapy)
- Cytokines
(blood)
- Emulsions
- Energy Intake
- Enteral Nutrition
- Fatty Acids, Omega-3
(pharmacology, therapeutic use)
- Female
- Fish Oils
- Humans
- Inflammation Mediators
(blood)
- Intensive Care Units
- Interleukin-10
(blood)
- Interleukin-8
(blood)
- Length of Stay
- Male
- Tumor Necrosis Factor-alpha
(blood)
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