Potassium 2-(1-hydroxypentyl)-benzoate improves learning and memory deficits in chronic cerebral hypoperfused rats.

Abstract

Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB), the pre-drug of 3-n-butylphthalide (dl-NBP), had the significantly therapeutic effect on the acute cerebral ischemia. The present study was to investigate the effect of dl-PHPB on the cognitive deficits induced by chronic cerebral hypoperfusion. Rats were orally administered three doses of dl-PHPB (13, 39 and 129mg/kg), dl-NBP 100mg/kg, and piracetam 600mg/kg daily for 21 days after the bilateral permanent occlusion of the common carotid arteries. The results showed that dl-PHPB, dl-NBP and piracetam significantly improved the spatial learning and memory deficits, and the effectiveness of dl-PHPB at dose of 39mg/kg was strongest. Meanwhile, the drugs decreased superoxide dismutase activity, reduced lipid peroxide and astrocyte activation in the cortex of the hypoperfused rats. Furthermore, dl-PHPB markedly reduced white matter rarefaction. The results indicated that preventing neuropathological alterations, inhibiting oxidative damage and inflammatory reaction might contribute to the improvement of dl-PHPB on hypoperfusion-induced cognitive deficits. Therefore, dl-PHPB has therapeutic potential for the treatment of dementia caused by decrease of cerebral blood flow.

• Authors: Wanhong Zhao, Shaofeng Xu, Ying Peng, Xincai Ji, Dongxu Cao, Jiang Li, Bin Liu, Qiaoqiao Shi, Ling Wang, Xiaoliang Wang
• Journal: Neuroscience letters (Neurosci Lett) Vol. 541 Pg. 155-60 (Apr 29 2013) ISSN: 1872-7972 [Electronic] Ireland
• PMID: 23416317 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• 2-(1-hydroxypentyl)-benzoate
• Benzoates
• Pentanes

Topics

• Animals
• Arterial Occlusive Diseases (complications)
• Astrocytes (drug effects, physiology)
• Benzoates (pharmacology)
• Brain (blood supply, drug effects, pathology)
• Carotid Artery Diseases (complications)
• Chronic Disease
• Learning Disabilities (drug therapy, etiology, psychology)
• Male
• Maze Learning (drug effects)
• Memory Disorders (drug therapy, etiology, psychology)
• Oxidative Stress (drug effects)
• Pentanes (pharmacology)
• Rats
• Rats, Wistar