IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection.

Abstract

Interleukin (IL)-21 may affect both T-cell and B-cell responses and was suggested to be involved in response to HBV infection. This study explored IL21rs907715 and rs2221903 and IL21R T-83C and rs3093301 polymorphisms and serum IL-21 and IgE levels in 395 patients with chronic HBV infection, 75 HBV infection resolvers and 174 healthy controls. IL21R T-83C was not polymorphic in the study populations. IL21 rs2221903 AG was less frequent in HBV patients than in resolvers (p<0.001, OR=0.364, 95% CI=0.211-0.629) or in controls (p=0.017, OR=0.589, 95% CI=0.381-0.911). IL21R rs3093301 TT was more frequent in HBV patients than in controls [p value after Bonferroni correction (pc)=0.022, OR=1.908, 95% CI=1.158-3.142] and more frequent in resolvers than in controls (pc=0.010, OR=2.965, 95% CI 1.375-6.392). The carriage of IL21 rs2221903 AG/IL21R rs3093301 CT+IL21 rs2221903 AG/IL21R rs3093301 TT was less frequent in patients than in resolvers (pc=0.007, OR=0.236, 95% CI=0.096-0.579) and more frequent in resolvers than in controls (pc=0.014, OR=4.354, 95% CI=1.660-11.420). IL21 rs2221903 was, by interaction with IL21R rs3093301, associated with serum IL-21 and IgE levels in HBV patients. It is suggested that IL21 rs2221903 and IL21R rs3093301 polymorphisms may, independently or interactively, affect the susceptibility to and/or persistence of HBV infection potentially through altering IL-21 and IgE production.

• Authors: Na Li, Qianqian Zhu, Zhu Li, Qunying Han, Jinghong Chen, Yi Lv, Yawen Wang, Xiaoyan Zeng, Yanping Chen, Cuiling Yang, Zhengwen Liu
• Journal: Human immunology (Hum Immunol) Vol. 74 Issue 5 Pg. 567-73 (May 2013) ISSN: 1879-1166 [Electronic] United States
• PMID: 23354321 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Chemical References

• Interleukins
• Receptors, Interleukin-21
• Immunoglobulin E
• interleukin-21

Topics

• Adult
• Alleles
• Epistasis, Genetic
• Female
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• Genotype
• Haplotypes
• Hepatitis B virus
• Hepatitis B, Chronic (blood, genetics, virology)
• Humans
• Immunoglobulin E (blood)
• Interleukins (blood, genetics)
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Polymorphism, Single Nucleotide
• Receptors, Interleukin-21 (genetics)
• Young Adult