Lubiprostone induced ischemic colitis.

Abstract

Ischemic colitis accounts for 6%-18% of the causes of acute lower gastrointestinal bleeding. It is often multifactorial and more commonly encountered in the elderly. Several medications have been implicated in the development of colonic ischemia. We report a case of a 54-year old woman who presented with a two-hour history of nausea, vomiting, abdominal pain, and bloody stool. The patient had recently used lubiprostone with close temporal relationship between the increase in the dose and her symptoms of rectal bleeding. The radiologic, colonoscopic and histopathologic findings were all consistent with ischemic colitis. Her condition improved without any serious complications after the cessation of lubiprostone. This is the first reported case of ischemic colitis with a clear relationship with lubiprostone (Naranjo score of 10). Clinical vigilance for ischemic colitis is recommended for patients receiving lubiprostone who are presenting with abdominal pain and rectal bleeding.

• Authors: Muhammed Sherid, Humberto Sifuentes, Salih Samo, Parakkal Deepak, Subbaramiah Sridhar
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 19 Issue 2 Pg. 299-303 (Jan 14 2013) ISSN: 2219-2840 [Electronic] United States
• PMID: 23345954 (Publication Type: Case Reports, Journal Article)

Chemical References

• Chloride Channel Agonists
• Lubiprostone
• Alprostadil

Topics

• Alprostadil (adverse effects, analogs & derivatives, therapeutic use)
• Chloride Channel Agonists
• Colitis, Ischemic (chemically induced, complications, diagnosis)
• Constipation (drug therapy)
• Female
• Hemorrhage (etiology)
• Humans
• Lubiprostone
• Middle Aged
• Withholding Treatment