Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation.

Abstract

There is much evidence that neuropeptide substance P is involved in neurogenic inflammation and is an important neurotransmitter and neurmodulator compound. In addition, substance P plays an important role in inflammation and immunity. Macrophages can be activated by substance P which provokes the release of inflammatory compounds such as interleukins, chemokines and growth factors. Substance P is involved in the mechanism of pain through the trigeminal nerve which runs through the head, temporal and sinus cavity. Substance P also activates mast cells to release inflammatory mediators such as arachindonic acid compound, cytokines/chemokines and histamine. The release of these chemical mediators is crucial for inflammatory response. Among these mediators there are prostoglandins and leukotrines. Here we review the impact of substance P on inflammatory compounds.

• Authors: M Nicoletti, G Neri, G Maccauro, D Tripodi, G Varvara, A Saggini, G Potalivo, M L Castellani, M Fulcheri, M Rosati, E Toniato, A Caraffa, P Antinolfi, G Cerulli, F Pandolfi, R Galzio, P Conti, T C Theoharides
• Journal: International journal of immunopathology and pharmacology (Int J Immunopathol Pharmacol) 2012 Oct-Dec Vol. 25 Issue 4 Pg. 849-57 ISSN: 0394-6320 [Print] England
• PMID: 23298476 (Publication Type: Editorial, Review)

Chemical References

• Receptors, Neurokinin-1
• Arachidonic Acid
• Substance P
• Dinoprostone

Topics

• Animals
• Arachidonic Acid (biosynthesis, immunology)
• Capillary Permeability
• Dinoprostone (physiology)
• Humans
• Receptors, Neurokinin-1 (physiology)
• Substance P (physiology)