Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system.

Abstract

BACKGROUND:

Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between gastrointestinal immune responses and CNS autoimmunity.

METHODS:

Antibodies against gliadin, tissue transglutaminase (tTG), intrinsic factor (IF), parietal cells (PC) and Saccharomyces cerevisiae (ASCA) were screened in the sera of 45 patients with AQP4-seropositive neuromyelitis optica (NMO) and NMO spectrum diseases (NMO/NMO-SD), 17 patients with AQP4-seronegative NMO, 85 patients with clinically definite multiple sclerosis (MS), and 48 healthy controls (HC).

RESULTS:

Thirty-seven percentages of patients with AQP4-seropositive NMO/NMO-SD and 28% of patients with MS had at least one particular antibody in contrast to 8% of HC (P < 0.01, respectively). Antibodies were most common (46%) in AQP4-seropositive myelitis (P = 0.01 versus HS, P = 0.05 versus MS). Anti-gliadin and ASCA were more frequent in the AQP4-seropositive NMO-spectrum compared to controls (P = 0.01 and P < 0.05, respectively).

CONCLUSION:

Antibody responses against gastrointestinal antigens are common in MS and AQP4-seropositive NMO/NMO-SD, especially in longitudinally extensive myelitis.

• Authors: M Banati, P Csecsei, E Koszegi, H H Nielsen, G Suto, L Bors, A Trauninger, T Csepany, C Rozsa, G Jakab, T Molnar, A Berthele, S R Kalluri, T Berki, Z Illes
• Journal: European journal of neurology (Eur J Neurol) Vol. 20 Issue 11 Pg. 1492-5 (Nov 2013) ISSN: 1468-1331 [Electronic] England
• PMID: 23293933 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 The Author(s) European Journal of Neurology © 2013 EFNS.

Chemical References

• Aquaporin 4

Topics

• Adult
• Aquaporin 4 (immunology)
• Demyelinating Autoimmune Diseases, CNS (blood, immunology)
• Gastrointestinal Diseases (blood, immunology)
• Humans
• Multiple Sclerosis (blood, immunology)
• Neuromyelitis Optica (blood, immunology)