Abstract | BACKGROUND: Accumulating evidence shows that the novel anti-inflammatory cytokine IL-35 can efficiently suppress effector T cell activity and alter the progression of inflammatory and autoimmune diseases. The two subunits of IL-35, EBI3 and p35, are strongly expressed in human advanced plaque, suggesting a potential role of IL-35 in atherosclerosis and coronary artery disease (CAD). However, the plasma levels of IL-35 in patients with CAD have yet to be investigated. METHODS: RESULTS: The results showed that plasma IL-35 levels were significantly decreased in the SAP group (90.74±34.22 pg/ml), the UAP group (72.20±26.63 pg/ml), and the AMI group (50.21±24.69 pg/ml) compared with chest pain syndrome group (115.06±32.27 pg/ml). Similar results were also demonstrated with IL-10 and TGF-β1. Plasma IL-12 and IL-27 levels were significantly increased in the UAP group (349.72±85.22 pg/ml, 101.75±51.42 pg/ml, respectively) and the AMI group (318.05±86.82 pg/ml, 148.88±68.45 pg/ml, respectively) compared with chest pain syndrome group (138.68±34.37 pg/ml, 63.60±22.75 pg/ml, respectively) and the SAP group (153.84±53.86 pg/ml, 70.84±38.77 pg/ml, respectively). Furthermore, lower IL-35 levels were moderately positively correlated with left ventricular ejection fraction (LVEF) in CAD patients (R = 0.416, P<0.01), whereas higher IL-27 levels were weakly negatively correlated with LVEF in CAD patients(R = -0.205, P<0.01). CONCLUSIONS: The results of the present study show that circulating IL-35 is a potentially novel biomarker for coronary artery disease. Regulating the expression of IL-35 also provides a new possible target for the treatment of atherosclerosis and CAD.
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Authors | Yingzhong Lin, Ying Huang, Zhengde Lu, Cheng Luo, Ying shi, Qiutang Zeng, Yifeng Cao, Lin Liu, Xiaoyan Wang, Qingwei Ji |
Journal | PloS one
(PLoS One)
Vol. 7
Issue 12
Pg. e52490
( 2012)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23285065
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Interleukins
- MYDGF protein, human
- interleukin-35, human
- Clopidogrel
- Ticlopidine
- Aspirin
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Topics |
- Aspirin
(pharmacology)
- Clopidogrel
- Coronary Artery Disease
(blood, physiopathology)
- Cytokines
(blood)
- Female
- Humans
- Interleukins
(blood)
- Male
- Middle Aged
- Statistics, Nonparametric
- Stroke Volume
(drug effects)
- Ticlopidine
(analogs & derivatives, pharmacology)
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