Abstract | OBJECTIVE: Patients with epilepsy after encephalitis/ encephalopathy (EAE) are often on polytherapy with anti-epileptic drugs (AEDs), and are at risk of adverse reactions. We examined the adverse effects of AEDs, especially sleepiness, in these patients. METHODS: RESULT: CONCLUSION: Long-lasting blood-brain barrier dysfunction and proliferation of immature vessels induced by IL-8 may contribute to the occurrence of sleepiness as an adverse effect of AEDs in patients with EAE. We recommend to assess for blood-brain barrier dysfunction when choosing AEDs for treating patients with intractable EAE.
|
Authors | Yukiko Mogami, Yukitoshi Takahashi, Tomohiro Fukuyama, Rumiko Takayama, Hideyuki Ohtani, Hiroko Ikeda, Katsumi Imai, Hideo Shigematsu, Yushi Inoue |
Journal | No to hattatsu = Brain and development
(No To Hattatsu)
Vol. 44
Issue 6
Pg. 472-6
(Nov 2012)
ISSN: 0029-0831 [Print] Japan |
PMID | 23240529
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
|
Topics |
- Adolescent
- Adult
- Anticonvulsants
(adverse effects, therapeutic use)
- Blood-Brain Barrier
(drug effects, physiopathology)
- Child
- Child, Preschool
- Encephalitis
(drug therapy)
- Epilepsy
(drug therapy)
- Female
- Humans
- Infant
- Infant, Newborn
- Male
- Middle Aged
- Retrospective Studies
- Sleep
(physiology)
- Young Adult
|