A clinicopathological study of resected small-sized squamous cell carcinomas of the peripheral lung: prognostic significance of serum carcinoembryonic antigen levels.

Abstract

PURPOSE:

The purpose of this retrospective study was to evaluate common clinicopathological factors and clarify the prognostic factors of small-sized peripheral-lung squamous cell carcinomas.

METHODS:

We retrospectively reviewed 71 patients with peripheral squamous cell carcinoma ≤3 cm in diameter, who were surgically treated between January 1989 and December 2010. Patients undergoing partial lung resection without lymph node dissection were excluded. The median follow-up for living patients was 63 months.

RESULTS:

The overall 3- and 5-year survival rates were 83.9% and 74.7%, respectively.Although the ROC curve of serum carcinoembryonic antigen (CEA) levels showed marginally significance (P = 0.050), multivariate analyses revealed that age (P = 0.043), lymph node metastasis (P = 0.004), and preoperative serum carcinoembryonic antigen (CEA) level (P = 0.037) were independent prognostic factors. For pathologic N0 patients, there was a significant difference for recurrence-free survival based on CEA levels: patients with normal CEA levels (n = 40), 5-year-recurrence-free rate = 93.5%;elevated CEA (n = 14), 5-year-recurrence-free rate = 72.7% (P = 0.0160). The distribution of tumor cells immunoreactive for CEA was significantly associated with serum CEA levels (P = 0.033).

CONCLUSION:

Age, lymph node metastasis, and serum CEA level are independent prognostic factors for small-sized peripheral-lung squamous cell carcinoma.

• Authors: Takuya Nagashima, Yukinori Sakao, Mingyon Mun, Yuichi Ishikawa, Ken Nakagawa, Munetaka Masuda, Sakae Okumura
• Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia (Ann Thorac Cardiovasc Surg) Vol. 19 Issue 5 Pg. 351-7 ( 2013) ISSN: 2186-1005 [Electronic] Japan
• PMID: 23237927 (Publication Type: Journal Article)

Chemical References

• Carcinoembryonic Antigen

Topics

• Age Factors
• Aged
• Aged, 80 and over
• Carcinoembryonic Antigen (blood)
• Carcinoma, Squamous Cell (blood, mortality, pathology, surgery)
• Chi-Square Distribution
• Disease-Free Survival
• Female
• Humans
• Kaplan-Meier Estimate
• Lung Neoplasms (blood, mortality, pathology, surgery)
• Lymph Node Excision
• Lymphatic Metastasis
• Male
• Middle Aged
• Multivariate Analysis
• Pneumonectomy (adverse effects, mortality)
• Proportional Hazards Models
• Retrospective Studies
• Risk Factors
• Survival Rate
• Time Factors
• Treatment Outcome
• Tumor Burden