Increased toll-like receptor 2 expression in peptidoglycan-treated blood monocytes is associated with insulin resistance in patients with nondiabetic rheumatoid arthritis.

Abstract

The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) cholesterol, were closely correlated with HOMA (homoeostasis model assessment) index in patients with nondiabetic RA. Expressions of TLR2 in peripheral blood monocytes, following stimulation with peptidoglycan which is known as a TLR2 agonist, were closely correlated with the HOMA index, TNF-α, and IL-6 concentrations. Accordingly, TLR-2 receptor and its related inflammatory cytokines could be potential therapeutic targets in managing insulin resistance in RA patients.

• Authors: Shih-Wei Wang, Tsun-Mei Lin, Chiou-Huey Wang, Hsiao-Han Liu, Jer-Yiing Houng
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2012 Pg. 690525 ( 2012) ISSN: 1466-1861 [Electronic] United States
• PMID: 23213270 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL
• Interleukin-6
• Peptidoglycan
• TLR2 protein, human
• Toll-Like Receptor 2
• Triglycerides
• Tumor Necrosis Factor-alpha

Topics

• Adult
• Aged
• Aged, 80 and over
• Arthritis, Rheumatoid (metabolism)
• Cholesterol, HDL (blood)
• Female
• Humans
• Insulin Resistance
• Interleukin-6 (blood)
• Male
• Middle Aged
• Monocytes (metabolism)
• Peptidoglycan (pharmacology)
• Toll-Like Receptor 2 (blood, physiology)
• Triglycerides (blood)
• Tumor Necrosis Factor-alpha (blood)