Hypoglossal nerve palsy missed and misinterpreted: the hidden skull base.

Abstract

OBJECTIVE:

Dysarthria and tongue swelling may be seen with hypoglossal nerve palsy, and on cross-sectional imaging studies, tongue denervation can be misinterpreted as a primary base-of-tongue mass. Understanding radiological patterns of tongue denervation is important to prevent misinterpretation. Close evaluation of the skull base is critical as hypoglossal palsies resulting from pathology here are often overlooked.

METHODS:

Neck and brain magnetic resonance imaging studies obtained in 7 adult patients referred to our institution with clinically and/or radiologically suspected tongue base masses were retrospectively reviewed. Outside imaging evaluations were misinterpreted as base-of-tongue tumors in 3 patients, incorrectly read as normal in 2, and skull base pathologies were missed in 5.

RESULTS:

All 7 patients showed magnetic resonance imaging findings typical of tongue denervation: T2-weighted hyperintensity of involved hemitongue, protrusion of the tongue into oropharynx, variable fatty infiltration. All 5 skull base masses involved hypoglossal canal (4 metastases, 1 multiple myeloma; 4 newly diagnosed cancers). Two patients had internal carotid artery dissections at the skull base.

CONCLUSIONS:

To avoid misinterpretation of tongue denervation for tongue base mass, understanding of tongue innervations and classic imaging findings of hypoglossal denervation are essential. Careful inspection of skull base is paramount to avoid overlooking these hidden pathologies.

• Authors: Kim O Learned, Erica R Thaler, Bert W O'Malley Jr, M Sean Grady, Laurie A Loevner
• Journal: Journal of computer assisted tomography (J Comput Assist Tomogr) 2012 Nov-Dec Vol. 36 Issue 6 Pg. 718-24 ISSN: 1532-3145 [Electronic] United States
• PMID: 23192210 (Publication Type: Case Reports, Journal Article)

Chemical References

• Contrast Media
• Gadolinium

Topics

• Adult
• Aged
• Carotid Artery, Internal, Dissection (complications, diagnosis, pathology)
• Contrast Media
• Diagnosis, Differential
• Diagnostic Errors
• Diffusion Magnetic Resonance Imaging
• Echo-Planar Imaging (methods)
• Female
• Gadolinium
• Humans
• Hypoglossal Nerve (pathology)
• Hypoglossal Nerve Diseases (complications, diagnosis, pathology)
• Image Enhancement
• Image Processing, Computer-Assisted (methods)
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Observer Variation
• Skull Base (pathology)
• Skull Base Neoplasms (complications, diagnosis, pathology)
• Tongue (innervation, pathology)