Elevated C1rC1sC1inh levels independently predict atherosclerotic coronary heart disease.

Abstract

UNLABELLED:

Clinical studies as well as animal models emphasized the importance of the complement system in the pathogenesis of coronary atherosclerosis and cardiovascular diseases. Our aim was to examine the extent and clinical implication of complement system activation in patients with stable atherosclerotic coronary heart disease (ACHD). Seventy-six patients with stable angina pectoris (SAP) scheduled for elective coronary angiography were enrolled into the study. Percutaneous coronary intervention (PCI) was performed in 24 patients, in 27 patients (NOPCI group) the coronary angiography showed significant stenosis and bypass surgery (CABG) or optimal medical therapy (OMT) were advised, whereas in 25 patients the coronary angiography was negative (NC group). 115 volunteers served as healthy controls (HC). In all individuals, the plasma level of several complement activation products - C1rC1sC1inh, C3bBbP and SC5b-9 - were determined on admission, strictly before the coronary angiography. In patients with angiographically proven ACHD (PCI and NOPCI groups), the baseline C1rC1sC1inh levels were significantly higher compared to NC group and HC (p<0.0001, for both comparisons). According to the multiple logistic regression analysis, high C1rC1sC1inh level proved to be an independent biomarker of coronary heart disease (p<0.026, OR: 65.3, CI: 1.628-2616.284).

CONCLUSION:

Activation of the classical complement pathway can be observed in angiographically proven coronary atherosclerosis. Elevated C1rC1sC1inh levels might represent an useful biomarker for coronary artery disease.

• Authors: Zsófia Horváth, Dorottya Csuka, Katarina Vargova, Andrea Kovács, Andrea Ágnes Molnár, Petra Gulácsi-Bárdos, Sarolta Leé, Lilian Varga, Róbert Gábor Kiss, István Préda, George Füst
• Journal: Molecular immunology (Mol Immunol) Vol. 54 Issue 1 Pg. 8-13 (May 2013) ISSN: 1872-9142 [Electronic] England
• PMID: 23174605 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Complement C1
• Complement C1 Inactivator Proteins
• Complement C1r
• Complement C1s

Topics

• Aged
• Atherosclerosis (blood, diagnosis)
• Case-Control Studies
• Cohort Studies
• Complement Activation (physiology)
• Complement C1 (analysis, metabolism)
• Complement C1 Inactivator Proteins (analysis, metabolism)
• Complement C1r (analysis, metabolism)
• Complement C1s (analysis, metabolism)
• Coronary Artery Disease (blood, diagnosis)
• Female
• Humans
• Male
• Middle Aged
• Prognosis