Abstract | BACKGROUND: OBJECTIVE: The objective was to prospectively examine the association of caffeinated compared with caffeine-free beverages, including coffee, tea, sugar-sweetened beverages (SSBs), and carbonated artificially sweetened beverages (ASBs), with T2D risk. DESIGN: We prospectively observed 74,749 women from the Nurses' Health Study (NHS, 1984-2008) and 39,059 men from the Health Professionals Follow-Up Study (HPFS, 1986-2008) who were free of diabetes, cardiovascular diseases, and cancer at baseline. RESULTS: We documented 7370 incident cases of T2D during 24 y of follow-up in the NHS and 2865 new cases during 22 y of follow-up in the HPFS. After major lifestyle and dietary risk factors were controlled for, caffeinated and caffeine-free SSB intake was significantly associated with a higher risk of T2D in the NHS (RR per serving: 13% for caffeinated SSBs, 11% for caffeine-free SSBs; P < 0.05) and in the HPFS (RR per serving: 16% for caffeinated SSBs, 23% for caffeine-free SSBs; P < 0.01). Only caffeine-free ASB intake in NHS participants was associated with a higher risk of T2D (RR: 6% per serving; P < 0.001). Conversely, the consumption of caffeinated and decaffeinated coffee was associated with a lower risk of T2D [RR per serving: 8% for both caffeinated and decaffeinated coffee in the NHS (P < 0.0001) and 4% for caffeinated and 7% for decaffeinated coffee in the HPFS (P < 0.01)]. Only caffeinated tea was associated with a lower T2D risk among NHS participants (RR per serving: 5%; P < 0.0001). CONCLUSION: Irrespective of the caffeine content, SSB intake was associated with a higher risk of T2D, and coffee intake was associated with a lower risk of T2D.
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Authors | Shilpa N Bhupathiraju, An Pan, Vasanti S Malik, JoAnn E Manson, Walter C Willett, Rob M van Dam, Frank B Hu |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 97
Issue 1
Pg. 155-66
(Jan 2013)
ISSN: 1938-3207 [Electronic] United States |
PMID | 23151535
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Coffee
- Sweetening Agents
- Tea
- Caffeine
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Topics |
- Adult
- Aged
- Beverages
- Body Mass Index
- Caffeine
(administration & dosage, analysis)
- Carbonated Beverages
- Coffee
- Diabetes Mellitus, Type 2
(etiology, physiopathology, prevention & control)
- Diet
- Female
- Follow-Up Studies
- Humans
- Life Style
- Male
- Middle Aged
- Multivariate Analysis
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Surveys and Questionnaires
- Sweetening Agents
- Tea
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