HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo.

Abstract
Therapeutic effects of hybrid liposomes (HL) composed of l-α-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(25) dodecyl ether (C(12)(EO)(25)) on the metastasis of human colon carcinoma (HCT116) cells were examined in vivo. Remarkably high therapeutic effects were obtained in the xenograft mouse models of colorectal cancer (CRC) liver metastases after treatment with HL-25 on the basis of relative liver weight and histological analysis of the liver tissue sections of mouse models with HE staining, and TUNEL staining for detection of apoptotic cells. The survival effects of HL-25 were obtained using xenograft mouse models of CRC liver metastases. Furthermore, with regard to pharmacokinetics, the accumulation of fluorescent labeled HL-25 was observed in the liver tissue of xenograft mouse models of CRC liver metastases for 24 h after the intravenous injection of fluorescent labeled HL-25. Therapeutic effects of HL without any drugs on the liver metastasis of human CRC were revealed for the first time in vivo.
AuthorsHideaki Ichihara, Motoki Hino, Masayo Umebayashi, Yoko Matsumoto, Ryuichi Ueoka
JournalEuropean journal of medicinal chemistry (Eur J Med Chem) Vol. 57 Pg. 143-8 (Nov 2012) ISSN: 1768-3254 [Electronic] France
PMID23059544 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Masson SAS. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Fluorescent Dyes
  • Liposomes
  • polyoxyethylene(25)dodecyl ether
  • Polyethylene Glycols
  • Dimyristoylphosphatidylcholine
Topics
  • Animals
  • Antineoplastic Agents (chemistry, pharmacology)
  • Apoptosis (drug effects)
  • Carcinoma (drug therapy, mortality, secondary)
  • Colorectal Neoplasms (drug therapy, mortality, pathology)
  • Dimyristoylphosphatidylcholine (chemistry, pharmacology)
  • Female
  • Fluorescent Dyes
  • Humans
  • In Situ Nick-End Labeling
  • Injections, Intravenous
  • Liposomes (chemistry, pharmacology)
  • Liver Neoplasms (drug therapy, mortality, secondary)
  • Mice
  • Mice, SCID
  • Organ Size (drug effects)
  • Polyethylene Glycols (chemistry, pharmacology)
  • Survival Rate
  • Xenograft Model Antitumor Assays

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: