Haemophagocytic syndrome associated with mucormycosis infection.

Abstract

Several clinical forms of mucormycosis are recognized. The tendency of mucoraceous zygomycetes to invade the blood vessels often produces a disseminated infection. A case of disseminate mucormycosis complicated by a haemophagocytic syndrome (HS) in a 32-year-old Caucasian male is reported in this article. Few cases of infection-associated HS (IAHS), involving infections caused by fungi, have been reported. In all the recorded cases, the fungal infection coexists with malignant lymphoma, immunodeficiency and a long-term steroid therapy for renal transplant or Crohn's disease. This is the second described case of the HS due to mucormycosis.

• Authors: V Arena, F De-Giorgio, I Pennacchia, R Manna, G Vetrugno, E Stigliano, N Milic, G Gasbarrini, L Abenavoli
• Journal: International journal of immunopathology and pharmacology (Int J Immunopathol Pharmacol) 2012 Jul-Sep Vol. 25 Issue 3 Pg. 751-5 ISSN: 0394-6320 [Print] England
• PMID: 23058025 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents

Topics

• Adult
• Autopsy
• Biopsy
• Bone Marrow Examination
• Fatal Outcome
• Gastric Mucosa (pathology)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Liver (pathology)
• Lymphohistiocytosis, Hemophagocytic (diagnosis, drug therapy, microbiology)
• Male
• Mucormycosis (complications, diagnosis, drug therapy, microbiology)
• Predictive Value of Tests
• Treatment Outcome