Evaluation of antihypertensive and antihyperlipidemic effects of bamboo shoot angiotensin converting enzyme inhibitory peptide in vivo.

Abstract

Cardiovascular protective functions of bamboo shoot angiotensin converting enzyme (ACE) inhibitory peptide (BSP) from bamboo shoot were evaluated, including antihypertensive effect on spontaneously hypertensive rats (SHRs) and antihyperlipidemic effect on high-fat-diet-induced rats. Thirty-day antihypertensive effects of BSP on SHRs were assayed. Asp-Tyr [10 mg/day kg body weight (BW)] and BSP (50 mg/day kg BW) significantly reduced ACE activity in lung at the same level (p < 0.05), while BSP (50 mg/day kg BW) reduced systolic blood pressure (SBP) more effectively for its phenolic compounds, such as ferulic acid and p-coumaric acid, which when combined with ACE inhibitor exert a synergistic effect. BSP could significantly reduce SBP, improve oxidant stress status (GSH-Px, SOD, TAC and MDA), and increase NO level in serum and NOS activity in kidney. BSP decreased total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) content and MDA level of hyperlipidemic rats, which might contribute to the ACE inhibitory capacity of Asp-Tyr and the fatty acid synthase inhibitory activity of phenolic compounds.

• Authors: Lianliang Liu, Lingyi Liu, Baiyi Lu, Daozong Xia, Ying Zhang
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 60 Issue 45 Pg. 11351-8 (Nov 14 2012) ISSN: 1520-5118 [Electronic] United States
• PMID: 23046038 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Antihypertensive Agents
• Coumaric Acids
• Hypolipidemic Agents
• Peptides
• Plant Extracts

Topics

• Angiotensin-Converting Enzyme Inhibitors (administration & dosage)
• Animals
• Antihypertensive Agents (administration & dosage)
• Blood Pressure (drug effects)
• Coumaric Acids (administration & dosage)
• Humans
• Hyperlipidemias (drug therapy, metabolism, physiopathology)
• Hypertension (drug therapy, metabolism, physiopathology)
• Hypolipidemic Agents (administration & dosage)
• Male
• Oxidative Stress (drug effects)
• Peptides (administration & dosage)
• Plant Extracts (administration & dosage)
• Plant Shoots (chemistry)
• Poaceae (chemistry)
• Rats
• Rats, Inbred SHR