Abstract | BACKGROUND AND PURPOSE: METHODS: Blood samples were collected from 17 patients, median age 61 (39-77) years, with sonographically verified rotator cuff tears (partial- or full-thickness). These were compared with 16 age- and sex-matched control individuals with sonographically intact rotator cuffs. Plasma levels of MMPs and TIMPs were measured simultaneously using Luminex technology and ELISA. RESULTS: The plasma levels of TIMP-1 were elevated in patients with rotator cuff tears, especially in those with full-thickness tears. The levels of TIMP-1, TIMP-3, and MMP-9 were higher in patients with full-thickness tears than in those with partial-thickness tears, but only the TIMP-1 levels were significantly different from those in the controls. INTERPRETATION: The observed elevation of TIMP-1 in plasma might reflect local pathological processes in or around the rotator cuff, or a genetic predisposition in these patients. That the levels of TIMP-1 and of certain MMPs were found to differ significantly between partial and full-thickness tears may reflect the extent of the lesion or different etiology and pathomechanisms.
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Authors | Hanna C Björnsson Hallgren, Pernilla Eliasson, Per Aspenberg, Lars E Adolfsson |
Journal | Acta orthopaedica
(Acta Orthop)
Vol. 83
Issue 5
Pg. 523-8
(Oct 2012)
ISSN: 1745-3682 [Electronic] Sweden |
PMID | 23043271
(Publication Type: Journal Article)
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Chemical References |
- Tissue Inhibitor of Metalloproteinase-1
- Tissue Inhibitor of Metalloproteinases
- Matrix Metalloproteinases
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Topics |
- Adult
- Aged
- Humans
- Matrix Metalloproteinases
(blood)
- Middle Aged
- Rotator Cuff
(diagnostic imaging)
- Rotator Cuff Injuries
- Tendon Injuries
(blood, diagnostic imaging)
- Tissue Inhibitor of Metalloproteinase-1
(blood)
- Tissue Inhibitor of Metalloproteinases
(blood)
- Ultrasonography
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