Abstract | BACKGROUND: Whether cardiac troponin concentrations are increased by reversible myocardial ischemia is controversial. Differences in the structure of cardiac troponin I (cTnI) and cTnT may have implications for diagnostic utility. METHODS: cTnI was measured with a prototype high-sensitivity (hs) assay in 198 patients referred for myocardial perfusion imaging (MPI) before exercise stress testing, immediately after, and 1.5 and 4.5 h later. We categorized patients according to MPI results and compared hs-cTnI concentrations with hs-cTnT concentrations. RESULTS: Baseline hs-cTnI was higher in patients with reversible myocardial ischemia (n = 19) vs the other patients (n = 179): median 4.4 (quartiles 1-3: 2.3-7.1) vs 2.5 (1.4-4.3) ng/L, P = 0.003. Baseline hs-cTnI and hs-cTnT concentrations were correlated (r = 0.46, P < 0.001) and the areas under the ROC curve for hs-cTnI and hs-cTnT in diagnosing reversible ischemia were similar: 0.71 vs 0.69, P = 0.77. Whereas hs-cTnI increased immediately after exercise (P < 0.001 vs baseline measurements) in patients without ischemia, it increased after 4.5 h in patients with reversible ischemia (P = 0.01). The increment in hs-cTnI concentrations was comparable between groups; thus, measuring hs-cTnI after exercise stress testing did not improve diagnostic accuracy over baseline measurements, and hs-cTnI concentrations were not found to be associated with reversible myocardial ischemia in multivariate analysis. By linear regression analysis, age, male sex, history of hypertension, angiotensin-converting enzyme inhibitor use, and lower left ventricular ejection fraction were associated with higher baseline hs-cTnI concentrations. CONCLUSIONS: In patients referred to MPI, hs-cTnI concentrations were not closely associated with reversible myocardial ischemia, but rather were influenced by variables associated with structural alterations of the myocardium.
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Authors | Helge Røsjø, Gunnhild Kravdal, Arne Didrik Høiseth, Marit Jørgensen, Pirouz Badr, Ragnhild Røysland, Torbjørn Omland |
Journal | Clinical chemistry
(Clin Chem)
Vol. 58
Issue 11
Pg. 1565-73
(Nov 2012)
ISSN: 1530-8561 [Electronic] England |
PMID | 22997281
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 American Association for Clinical Chemistry |
Chemical References |
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Topics |
- Aged
- Exercise Test
- Female
- Humans
- Male
- Middle Aged
- Myocardial Ischemia
(diagnosis, physiopathology)
- Myocardial Perfusion Imaging
- Prospective Studies
- Regression Analysis
- Sensitivity and Specificity
- Troponin I
(blood)
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