Effects of C-Phycocyanin on the representative genes of tumor development in mouse skin exposed to 12-O-tetradecanoyl-phorbol-13-acetate.

Abstract

C-Phycocyanin (C-PC), a biliprotein from the sea weed, has been shown to have the beneficial effects like antioxidant, anti-inflammatory, neuroprotective, and hepatoprotective properties and is used as food supplement. We are showing the effect of C-Phycocyanin on the early events altered by tumor promoter. TPA induced the expression of critical events of tumorigenesis like ornithine decarboxylase, cyclooxygenase-2, interleukin-6 and pSTAT3 in mouse skin after 5h of application, whereas expression of transglutaminase2 was decreased at this time point. This TPA-caused altered expression of genes was prevented in presence of C-Phycocyanin. This prevention by C-Phycocyanin appeared to be dependent on the dose of C-Phycocyanin used. The results are useful for the detailed study on the preventive effect of C-Phycocyanin on TPA induced tumor promotion.

• Authors: Naresh Kumar Gupta, Krishna P Gupta
• Journal: Environmental toxicology and pharmacology (Environ Toxicol Pharmacol) Vol. 34 Issue 3 Pg. 941-8 (Nov 2012) ISSN: 1872-7077 [Electronic] Netherlands
• PMID: 22986104 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Carcinogens
• Interleukin-6
• Phycocyanin
• Cyclooxygenase 2
• Ornithine Decarboxylase
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Carcinogens (toxicity)
• Cyclooxygenase 2 (genetics, metabolism)
• Female
• Gene Expression
• Interleukin-6 (genetics, metabolism)
• Mice
• Ornithine Decarboxylase (genetics, metabolism)
• Phycocyanin (genetics, metabolism)
• Skin (metabolism, pathology)
• Skin Neoplasms (genetics, metabolism)
• Tetradecanoylphorbol Acetate (toxicity)