Swim training of monosodium L-glutamate-obese mice improves the impaired insulin receptor tyrosine phosphorylation in pancreatic islets.

Abstract

The goal of the present study was to investigate changes on glucose homoeostasis and of the insulin receptor (IR) and insulin receptor substrate-1 (IRS-1) signalling in pancreatic islets from MSG-obese mice submitted to or not submitted to swim training. Swim training of 90-day-old MSG mice was used to evaluate whether signalling pathways of the IR and IRS-1 in islets are involved with the insulin resistance and glucose intolerance observed in this obese animal model. The results showed that IR tyrosine phosphorylation (pIR) was reduced by 42 % in MSG-obese mice (MSG, 6.7 ± 0.2 arbitrary units (a.u.); control, 11.5 ± 0.4 a.u.); on the other hand, exercise training increased pIR by 76 % in MSG mice without affecting control mice (MSG, 11.8 ± 0.3; control, 12.8 ± 0.2 a.u.). Although the treatment with MSG increased IRS-1 tyrosine phosphorylation (pIRS-1) by 96 % (MSG, 17.02 ± 0.6; control, 8.7 ± 0.2 a.u.), exercise training also increased it in both groups (control, 13.6 ± 0.1; MSG, 22.2 ± 1.1 a.u.). Current research shows that the practice of swim training increases the tyrosine phosphorylation of IRS-1 which can modulate the effect caused by obesity in insulin receptors.

• Authors: Rosiane Aparecida Miranda, Renato Chaves Souto Branco, Clarice Gravena, Luiz Felipe Barella, Claudinéia Conationi da Silva Franco, Ana Eliza Andreazzi, Júlio Cezar de Oliveira, Maria Cecília Picinato, Paulo Cezar de Freitas Mathias
• Journal: Endocrine (Endocrine) Vol. 43 Issue 3 Pg. 571-8 (Jun 2013) ISSN: 1559-0100 [Electronic] United States
• PMID: 22983867 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Insulin
• Receptor, Insulin
• Glucose
• Sodium Glutamate

Topics

• Animals
• Blood Glucose (metabolism)
• Glucose (pharmacology)
• Insulin (metabolism)
• Insulin Resistance
• Islets of Langerhans (drug effects, metabolism)
• Male
• Mice
• Obesity (chemically induced, metabolism)
• Phosphorylation (drug effects)
• Physical Conditioning, Animal (physiology)
• Receptor, Insulin (metabolism)
• Sodium Glutamate
• Swimming (physiology)