Abstract | BACKGROUND: METHODS: A total of 270 patients were enrolled in the study, and we measured urinary NAG, β2-microglobulin, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) prospectively for 1 year to compare their predictive values for renal function. RESULTS: Baseline urinary NAG/Cr was negatively correlated with estimated glomerular filtration rate (GFR) (r2 = 0.153, P < 0.001) and positively correlated with total kidney volume (TKV) (r2 = 0.113, P < 0.001). Among other biomarkers, urinary NAG/Cr better discriminated patients with decreased renal function from those with conserved renal function, showing the largest area under the curve (AUC 0.794). Immunohistochemical study revealed strong staining along the cyst-lining epithelial cells as well as the nearby compressed tubular epithelial cells. However, both single and repeated measurements of urinary NAG/Cr failed to predict renal function decline in 1 year. CONCLUSIONS:
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Authors | Hayne Cho Park, Jin Ho Hwang, Ah-Young Kang, Han Ro, Myung-Gyu Kim, Jung Nam An, Ji In Park, Seung Hyup Kim, Jaeseok Yang, Yun Kyu Oh, Kook-Hwan Oh, Jung Woo Noh, Hae Il Cheong, Young-Hwan Hwang, Curie Ahn |
Journal | BMC nephrology
(BMC Nephrol)
Vol. 13
Pg. 93
(Aug 30 2012)
ISSN: 1471-2369 [Electronic] England |
PMID | 22935351
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Acetylglucosaminidase
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Topics |
- Acetylglucosaminidase
(urine)
- Adult
- Biomarkers
(urine)
- Cohort Studies
- Female
- Humans
- Kidney Function Tests
(statistics & numerical data)
- Longitudinal Studies
- Male
- Polycystic Kidney, Autosomal Dominant
(diagnosis, epidemiology, urine)
- Prevalence
- Prospective Studies
- Reproducibility of Results
- Republic of Korea
(epidemiology)
- Risk Assessment
(methods)
- Sensitivity and Specificity
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