Abstract | BACKGROUND: METHODS: Twenty-one eyes of 21 BRVO patients with macular edema received IVTA. Patients were divided into two groups by optical coherence tomography findings: 11 patients who had cystoid macular edema (CME) with SRD (SRD (+) group) and 10 patients who had CME without SRD (SRD (-) group). Microperimetry was performed with a Micro Perimeter 1 before and at 3 and 6 months after IVTA. Macular thickness was measured by optical coherence tomography. We exchanged the superior and inferior regions to separate the regions into those with and without occlusion. As a result, the superior region was always the occluded region and the inferior region was non-occluded. RESULTS: In both the SRD (-) group and the SRD (+) group, the mean macular thickness within the central 4° field and the 10° and 20° fields of the occluded region decreased significantly from baseline to 3 and 6 months after IVTA (all P <0.01). Visual acuity also improved significantly in both groups from baseline to 3 and 6 months after IVTA (both P <0.05). In both groups, the mean macular sensitivity (measured with by microperimetry) within the central 4° field and the 10° and 20° fields of the occluded region showed a significant increase from baseline to 3 and 6 months after IVTA (all P <0.05). The trend profiles of macular thickness within the 10° and 20° fields of the occluded region showed significant differences, but there were no significant differences with respect to the trend profiles of visual acuity and macular sensitivity within the central 4° field and the 10° and 20° fields of the occluded region. CONCLUSIONS: These results suggest that IVTA may achieve more marked improvement of macular morphology in BRVO patients with SRD than in those without SRD, while this therapy may have a similar effect on macular function in BRVO patients with or without SRD.
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Authors | Hidetaka Noma, Hideharu Funatsu, Tatsuya Mimura, Katsunori Shimada |
Journal | BMC ophthalmology
(BMC Ophthalmol)
Vol. 12
Pg. 39
(Aug 09 2012)
ISSN: 1471-2415 [Electronic] England |
PMID | 22876931
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Glucocorticoids
- Triamcinolone Acetonide
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Topics |
- Aged
- Female
- Fluorescein Angiography
- Follow-Up Studies
- Fundus Oculi
- Glucocorticoids
(administration & dosage)
- Humans
- Intravitreal Injections
- Macula Lutea
(drug effects, pathology)
- Macular Edema
(complications, diagnosis, drug therapy)
- Male
- Prospective Studies
- Retinal Detachment
(complications, diagnosis, drug therapy)
- Retinal Vein Occlusion
(complications, diagnosis, drug therapy)
- Tomography, Optical Coherence
- Treatment Outcome
- Triamcinolone Acetonide
(administration & dosage)
- Visual Acuity
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