The association of serum lipocalin-2 levels with metabolic and clinical parameters in obese children: a pilot study.

Abstract

OBJECTIVE:

We aimed to evaluate the association between serum lipocalin-2 level and clinical and metabolic parameters in obese children.

METHODS:

The study included obese children with a body mass index (BMI) >95th percentile who presented to Kecioren Teaching and Research Hospital with the complaint of weight gain and healthy children with a BMI <85th percentile. The height and weight of the patients were measured for compartment of anthropometric data. Fasting blood glucose, insulin, lipid profile, and serum lipocalin-2 level were measured to evaluate the laboratory parameters.

RESULTS:

The study included 33 obese and 34 healthy nonobese children. Comparison of data on the obese subjects with those of the healthy subjects shows differences in BMI, BMI-SDS, triglyceride, insulin, and homeostasis model assessment index-insulin resistance levels between the two groups were statistically significant (p < 0.05), whereas serum lipocalin-2 was not statistically significant (p >0.05). There was no statistically significant difference in serum lipocalin-2 levels when obese and control groups were reclassified as prepubertal and pubertal ( p >0.05).

CONCLUSIONS:

In this study, we did not find any relationships among serum lipocalin-2 level, anthropometric parameters, or metabolic parameters. According to the results of this study, we do not suggest routine investigation of serum lipocalin-2 level in obese subjects for risk stratification of the obesity-related complications.

• Authors: Ahmet Zulfikar Akelma, Ayhan Abaci, Osman Ozdemir, Aydin Celik, Zekai Avci, Cem Hasan Razi, Samil Hizli, Okhan Akin
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 25 Issue 5-6 Pg. 525-8 ( 2012) ISSN: 0334-018X [Print] Germany
• PMID: 22876549 (Publication Type: Journal Article)

Chemical References

• Acute-Phase Proteins
• Blood Glucose
• LCN2 protein, human
• Lipid A
• Lipocalin-2
• Lipocalins
• Proto-Oncogene Proteins

Topics

• Acute-Phase Proteins
• Adolescent
• Blood Glucose (metabolism)
• Body Mass Index
• Child
• Female
• Homeostasis (physiology)
• Humans
• Insulin Resistance (physiology)
• Lipid A (blood)
• Lipocalin-2
• Lipocalins (blood)
• Male
• Obesity (blood, epidemiology)
• Pilot Projects
• Proto-Oncogene Proteins (blood)
• Risk Factors