Adipokines, insulin resistance and hyperandrogenemia in obese patients with polycystic ovary syndrome: cross-sectional correlations and the effects of weight loss.

Abstract

OBJECTIVE:

To assess the effects of weight loss on serum adipokine levels in polycystic ovary syndrome (PCOS).

METHODS:

We determined serum leptin, adiponectin, resistin, and visfatin levels in 60 overweight/obese women with PCOS and 48 BMI-matched female volunteers. Measurements were repeated after 24 weeks of treatment with orlistat 120 mg 3 times per day along with an energy-restricted diet.

RESULTS:

At baseline, serum visfatin concentration was higher in patients with PCOS than in controls (p = 0.036); serum levels of leptin, adiponectin, and resistin did not differ between the two groups. After 24 weeks, a significant reduction in BMI and waist circumference was observed in both patients with PCOS and controls (p < 0.001 vs. baseline in both groups). Also serum leptin levels decreased in both patients with PCOS and controls (p < 0.001 vs. baseline in both groups). The reduction in serum leptin levels did not differ between groups. Serum adiponectin, resistin, and visfatin levels did not change in either group.

CONCLUSIONS:

Leptin, adiponectin, and resistin do not appear to play major pathogenetic roles in overweight/obese patients with PCOS. In contrast, visfatin emerges as a potentially important mediator of the endocrine abnormalities of these patients. However, serum visfatin levels are not substantially affected by weight loss.

• Authors: Nikolaos Spanos, Konstantinos Tziomalos, Djuro Macut, Ekaterini Koiou, Eleni A Kandaraki, Dimitrios Delkos, Elena Tsourdi, Dimitrios Panidis
• Journal: Obesity facts (Obes Facts) Vol. 5 Issue 4 Pg. 495-504 ( 2012) ISSN: 1662-4033 [Electronic] Switzerland
• PMID: 22854419 (Publication Type: Journal Article)

Chemical References

• Adipokines
• Adiponectin
• Anti-Obesity Agents
• Lactones
• Leptin
• Resistin
• Orlistat
• Nicotinamide Phosphoribosyltransferase

Topics

• Adipokines (blood)
• Adiponectin (blood)
• Adult
• Anti-Obesity Agents (pharmacology, therapeutic use)
• Body Mass Index
• Case-Control Studies
• Cross-Sectional Studies
• Female
• Humans
• Hyperandrogenism (blood, complications, drug therapy)
• Insulin Resistance
• Lactones (pharmacology, therapeutic use)
• Leptin (blood)
• Nicotinamide Phosphoribosyltransferase (blood)
• Obesity (blood, complications, drug therapy)
• Orlistat
• Polycystic Ovary Syndrome (blood, complications, drug therapy)
• Resistin (blood)
• Waist Circumference (drug effects)
• Weight Loss (drug effects, physiology)
• Young Adult