Abstract | BACKGROUND: ILLUSTRATIVE CASES: DISCUSSION: Malignant transformation can occur in low-grade intramedullary neoplasms in children. This is a novel documented event for pediatric intramedullary spinal cord tumors and a rare event for all pediatric low-grade neuroepithelial tumors without induction by irradiation. A survey of the relevant literature reveals an underwhelming number of studies focusing on malignant transformation in children's CNS tumors relative to adults. Further investigation into molecular mechanisms of pediatric low-grade neoplasms may reveal more aggressive tumor sub-variants predisposed to malignant degeneration.
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Authors | E Winograd, N Pencovich, M Yalon, D Soffer, L Beni-Adani, S Constantini |
Journal | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
(Childs Nerv Syst)
Vol. 28
Issue 10
Pg. 1679-86
(Oct 2012)
ISSN: 1433-0350 [Electronic] Germany |
PMID | 22776978
(Publication Type: Case Reports, Journal Article, Review)
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Topics |
- Adolescent
- Astrocytoma
(pathology, physiopathology, surgery)
- Child, Preschool
- Disease Progression
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Spinal Cord Neoplasms
(pathology, physiopathology, surgery)
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