[A case of polycythemia vera associated with idiopathic interstitial pneumonia successfully treated by alkylating agents].

Abstract

A 62-year-old female was referred to our division because of general fatigue, low grade fever and exertional dyspnea for 2 months. Laboratory data and chest roentgenograms on admission revealed polycythemia vera associated with idiopathic interstitial pneumonia. Alkylating therapy with carboquone and cyclophosphamide resulted in the improvement of abnormalities on chest X-ray films which had previously shown decreased lung fields and abnormal interstitial shadows, as well as hematological abnormalities. Six months later, the results of the patient's pulmonary function tests and arterial blood gas analysis became within normal limits. Little information about polycythemia vera associated with idiopathic interstitial pneumonia is available. This case indicated that alkylating therapy with no steroidal combination is effective for idiopathic interstitial pneumonia.

• Authors: S Yagi, K Hashiguchi, M Nakajima, S Umeki, H Hara, R Soejima
• Journal: Nihon Kyobu Shikkan Gakkai zasshi (Nihon Kyobu Shikkan Gakkai Zasshi) Vol. 28 Issue 10 Pg. 1366-71 (Oct 1990) ISSN: 0301-1542 [Print] Japan
• PMID: 2273667 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Alkylating Agents
• Carbazilquinone
• Cyclophosphamide

Topics

• Alkylating Agents (therapeutic use)
• Carbazilquinone (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Female
• Humans
• Middle Aged
• Polycythemia Vera (complications, drug therapy)
• Pulmonary Fibrosis (complications, drug therapy)