Abstract | OBJECTIVE:
Copper is an essential mineral nutrient for humans. Serum copper levels of hemodialysis patients are higher than those of healthy subjects, but it remains to be elucidated whether increased serum copper may have harmful effects. In addition, a recent in vitro study has shown that sevelamer can adsorb copper. In the present study, we searched for clinical factors associated with serum copper levels in hemodialysis patients. METHODS: This cross-sectional study included patients undergoing hemodialysis for more than 6 months. In these patients, we statistically tested associations between serum copper levels and other parameters, including nutritional markers, lipid profiles, oxidative stress, inflammation, and sevelamer administration. RESULTS: CONCLUSION:
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Authors | Ryota Ikee, Masataka Tsunoda, Naomi Sasaki, Naritsugu Sato, Nobuo Hashimoto |
Journal | International urology and nephrology
(Int Urol Nephrol)
Vol. 45
Issue 3
Pg. 839-45
(Jun 2013)
ISSN: 1573-2584 [Electronic] Netherlands |
PMID | 22684797
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Chelating Agents
- Polyamines
- Copper
- Sevelamer
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Topics |
- Aged
- Chelating Agents
(therapeutic use)
- Copper
(blood)
- Cross-Sectional Studies
- Dyslipidemias
(blood, drug therapy, etiology)
- Female
- Follow-Up Studies
- Humans
- Kidney Failure, Chronic
(blood, therapy)
- Male
- Oxidative Stress
(drug effects)
- Polyamines
(administration & dosage)
- Renal Dialysis
(adverse effects)
- Sevelamer
- Time Factors
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