Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population.

Abstract

BACKGROUND:

Epidemiology and animal models suggest that dietary monosodium glutamate (MSG) may contribute to the onset of obesity and the metabolic syndrome.

METHODS:

Families (n = 324) from a rural area of Thailand were selected and provided MSG as the sole source for the use in meal preparation for 10 days. Three hundred forty-nine subjects aged 35-55 years completed the study and were evaluated for energy and nutrient intake, physical activity, and tobacco smoking. The prevalence of overweight and obesity (BMI ≥ 25 kg/m2), insulin resistance (HOMA-IR >3), and the metabolic syndrome (ATP III criteria) were evaluated according to the daily MSG intake.

RESULTS:

The prevalence of the metabolic syndrome was significantly higher in the tertile with the highest MSG intake. Further, every 1 g increase in MSG intake significantly increased the risk of having the metabolic syndrome (odds ratio 1.14, 95% confidence interval-CI- 1.12 - 1.28) or being overweight (odds ratio 1.16, 95% CI 1.04 - 1.29), independent of the total energy intake and the level of physical activity.

CONCLUSION:

Higher amounts of individual MSG consumption are associated with the risk of having the metabolic syndrome and being overweight independent of other major determinants.

• Authors: Tonkla Insawang, Carlo Selmi, Ubon Cha'on, Supattra Pethlert, Puangrat Yongvanit, Premjai Areejitranusorn, Patcharee Boonsiri, Tueanjit Khampitak, Roongpet Tangrassameeprasert, Chadamas Pinitsoontorn, Vitoon Prasongwattana, M Eric Gershwin, Bruce D Hammock
• Journal: Nutrition & metabolism (Nutr Metab (Lond)) Vol. 9 Issue 1 Pg. 50 (Jun 08 2012) ISSN: 1743-7075 [Electronic] England
• PMID: 22681873 (Publication Type: Journal Article)