Preoperative serum levels of matrix metalloproteinase-2 (MMP-2) and survival of breast cancer among Korean women.

Abstract

BACKGROUND:

Matrix metalloproteinase-2 (MMP-2) has been thought of as a predictor of recurrence or metastasis risk or prognostic markers in cancer. We evaluated whether preoperative serum levels of MMP-2 work as a prognostic biomarker in breast cancer prognosis.

METHODS:

Preoperative serum levels of MMP-2 were measured with ELISA in 303 patients with histologically confirmed breast cancer. The median follow-up time for all patients was 4.24 years. The relationship of MMP-2 to survival was investigated using Cox proportional hazard regression model adjusted for the tumor-node-metastasis (TNM) stage and estrogen receptor (ER) status.

RESULTS:

In the multivariate analysis, disease-free survival (DFS) was worse among patients with the third tertile of MMP-2 level than with the first tertile of MMP-2 level [hazard ratio, 1.80; 95% confidence interval (CI), 1.04-3.11; P = 0.04]. However, when the patients were stratified by age, ER status, histologic grade, and nuclear grade, inverse correlation was shown between serum MMP-2 levels and prognostic factors, and the associations between MMP-2 and DFS were only significant among patients with poor prognostic factors (HR, 2.75; 95% CI, 1.32-5.73 in ER-negative; HR, 2.90; 95% CI, 1.42-5.92 in histologic grade III; and HR, 2.61; 95% CI, 1.26-5.39 in nuclear grade III).

CONCLUSIONS:

Our results suggest that the preoperative serum levels of MMP-2 were associated with the survival in patients with breast cancer in ER-negative, higher histologic grade, or higher nuclear grade breast cancers.

IMPACT:

Our results indicate that serum levels of MMP-2 may play a role as prognostic biomarker in breast cancer survival.

• Authors: Nan Song, Hyuna Sung, Ji-Yeob Choi, Sohee Han, Sujee Jeon, Minkyo Song, Yunhee Lee, Chulbum Park, Sue K Park, Kyoung-Mu Lee, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Sang-Ah Lee, Daehee Kang
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 21 Issue 8 Pg. 1371-80 (Aug 2012) ISSN: 1538-7755 [Electronic] United States
• PMID: 22634108 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: ©2012 AACR.

Chemical References

• Biomarkers, Tumor
• Matrix Metalloproteinase 2

Topics

• Adult
• Biomarkers, Tumor (blood)
• Breast Neoplasms (enzymology, pathology, surgery)
• Disease-Free Survival
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Matrix Metalloproteinase 2 (blood)
• Middle Aged
• Multivariate Analysis
• Preoperative Period
• Prognosis
• Republic of Korea
• Survival Analysis